This gene encodes the CD4 membrane glycoprotein of T lymphocytes. The CD4 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class II MHC molecules. The CD4 antigen is also a primary receptor for entry of the human immunodeficiency virus through interactions with the HIV Env gp120 subunit. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, granulocytes, as well as in various regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene.
Aliases: IMD79; OKT4D; CD4mut
Entrez GeneID : 920
Swissprot : P01730
WB Predicted band size : 51kDa
Host/Isotype : Mouse IgG2b
Species Reactivity : Human
Immunogen : Purified recombinant fragment of human CD4 (AA: 26-170) expressed in E. Coli.
