This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene.
Aliases: FCC1; COCA1; HNPCC; LCFS2; hMSH2; HNPCC1
Entrez GeneID: 4436
Swissprot : P43246
WB Predicted band size : 104.7kDa
Host/Isotype: Mouse IgG2b
Species Reactivity : Human
Immunogen : Purified recombinant fragment of human MSH2 (AA: 442-586) expressed in E. Coli.
