This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene.
Aliases： FCC1; COCA1; HNPCC; LCFS2; hMSH2; HNPCC1; MMRCS2
Entrez GeneID： 4436
Swissprot ： P43246
WB Predicted band size ： 104.7kDa
Host/Isotype ： Mouse IgG1
Species Reactivity ： Human
Immunogen： Purified recombinant fragment of human MSH2 (AA: 2-151) expressed in E. Coli.
