This gene encodes a component of the polycomb multiprotein complex, which is required to maintain the transcriptionally repressive state of many genes throughout development via chromatin remodeling and modification of histones. Disruption of this gene in mice results in male-to-female gonadal sex reversal. Mutations in this gene are also associated with gonadal dysgenesis in humans. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Aliases: M33; CDCA6; SRXY5
Entrez GeneID: 84733
Swissprot : Q14781
WB Predicted band size: 56kDa
Host/Isotype: Mouse IgG1
Species Reactivity : Human,Mouse
Immunogen : Purified recombinant fragment of human CBX2 (AA: 402-525) expressed in E. Coli.
