Aurora A plays a role in cell cycle regulation during anaphase and/or telophase, in relation to the function of the centrosome/spindle pole region during chromosome segregation. Aurora A plays a key role during tumor development and progression and is overexpressed in many human cancers including breast, ovarian and colorectal. Aurora A is viewed as a potential target for anticancer drug treatment.Tissue specificity: Highly expressed in testis and weakly in skeletal muscle, thymus and spleen. Also highly expressed in colon, ovarian, prostate, neuroblastoma, breast and cervical cancer cell lines.
Aliases : AIK; ARK1; AURA; BTAK; STK6; STK7; STK15; AURORA2; MGC34538; AURKA
Entrez GeneID : 6790
Swissprot : O14965
WB Predicted band size : 48kDa
Host/Isotype : Mouse IgG1
Species Reactivity : Human,Mouse,Rat,Monkey
Immunogen : Purified recombinant fragment of human AURKA expressed in E. Coli.
