This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Aliases： SPHK2; SK-2; SPK 2; SPK-2
Entrez GeneID： 56848
Swissprot： Q9NRA0
WB Predicted band size： 69.2kDa
Host/Isotype： Mouse IgG1
Species Reactivity： Human
Immunogen： Synthesized peptide of human SK2 (AA: 36-52).
