Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in four transcript variants encoding different isoforms.
Aliases： p85; GRB1; p85-ALPHA
Entrez GeneID： 5295
Swissprot ： P27986
WB Predicted band size： 83.6kDa
Host/Isotype ： Mouse IgG1
Species Reactivity： Human,Mouse
Immunogen： Purified recombinant fragment of human PIK3R1 (AA: 159-388) expressed in E. Coli.
