Prohibitin is an evolutionarily conserved gene that is ubiquitously expressed. It is thought to be a negative regulator of cell proliferation and may be a tumor suppressor. Mutations in PHB have been linked to sporadic breast cancer. Prohibitin is expressed as two transcripts with varying lengths of 3' untranslated region. The longer transcript is present at higher levels in proliferating tissues and cells, suggesting that this longer 3' untranslated region may function as a trans-acting regulatory RNA.
Aliases： PHB1
Entrez GeneID： 5245
Swissprot： P35232
WB Predicted band size： 30kDa
Host/Isotype： Mouse IgG1
Species Reactivity： Human,Mouse,Rat,Monkey
Immunogen： Purified recombinant fragment of human PHB expressed in E. Coli.
