This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. The protein polymerizes into a gel of which 80% is composed of oligosaccharide side chains by weight. The protein features a central domain containing tandem repeats rich in threonine and proline that varies between 50 and 115 copies in different individuals. Downregulation of this gene has been observed in patients with Crohn disease and ulcerative colitis.
Aliases : MLP; SMUC; MUC-2
Entrez GeneID: 4583
Swissprot : Q02817
WB Predicted band size : 540kDa
Host/Isotype : Mouse IgG1
Species Reactivity : Human,Mouse,Rat,Rabbit
Immunogen : Purified recombinant fragment of human MUC2 (AA: 4373-4557) expressed in E. Coli.
