This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene.
Aliases： INrf2; KLHL19
Entrez GeneID： 9817
Swissprot ： Q14145
WB Predicted band size ： 69.7kDa
Host/Isotype ： Mouse IgG1
Species Reactivity ： Human,Mouse
Immunogen ： Purified recombinant fragment of human KEAP1 (AA: 380-624) expressed in E. Coli.
