ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.
Aliases： GT; GTA; CD41; GP2B; HPA3; CD41B; GPIIb; BDPLT2
Entrez GeneID： 3674
Swissprot： P08514
WB Predicted band size ： 113.4kDa
Host/Isotype ： Mouse IgG1
Species Reactivity： Human
Immunogen： Purified recombinant fragment of human ITGA2B (AA: 45-149) expressed in E. Coli.
