Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.
Aliases： HD1; RPD3; KDAC1; GON-10; RPD3L1
Entrez GeneID： 3065
Swissprot： Q13547
WB Predicted band size ： 55.1kDa
Host/Isotype ： Mouse IgG1
Species Reactivity： Human, Mouse
Immunogen ： Purified recombinant fragment of human HDAC1 (AA: 321-482) expressed in E. Coli.
