This gene encodes an integrin beta chain, which combines with multiple different alpha chains to form different integrin heterodimers. Integrins are integral cell-surface proteins that participate in cell adhesion as well as cell-surface mediated signalling. The encoded protein plays an important role in immune response and defects in this gene cause leukocyte adhesion deficiency. Alternative splicing results in multiple transcript variants.
Aliases ： ITGB2; LAD; CD18; MF17; MFI7; LCAMB; LFA-1; MAC-1
Entrez GeneID： 3689
Swissprot： P05107
WB Predicted band size： 84.8kDa
Host/Isotype： Mouse IgG1
Species Reactivity： Human
Immunogen： Purified recombinant fragment of human CD18 (AA: extra 559-700) expressed in E. Coli.
