This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. Two transcript variants encoding different isoforms have been found for this gene.
Aliases ： ITGAX; SLEB6
Entrez GeneID： 3687
Swissprot： P20702
WB Predicted band size： 127.8kDa
Host/Isotype ： Mouse IgG1
Species Reactivity： Human,Mouse
Immunogen： Purified recombinant fragment of human CD11C (AA: extra 102-279) expressed in E. Coli.
