ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene.
Aliases： ITGAL; LFA-1; LFA1A
Entrez GeneID： 3683
Swissprot ： P20701
WB Predicted band size： 128.8kDa
Host/Isotype ： Mouse IgG2a
Species Reactivity ： Human
Immunogen： Purified recombinant fragment of human CD11a (AA: extra 26-194) expressed in E. Coli.
