This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Aliases： NECTIN2; HVEB; PRR2; PVRL2; PVRR2
Entrez GeneID ： 5819
Swissprot： Q92692
WB Predicted band size： 57.7kDa
Host/Isotype ： Mouse IgG1
Species Reactivity： Human
Immunogen： Purified recombinant fragment of human CD112 (AA: extra 58-212) expressed in E. Coli.
