The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation.
Aliases: CBL; CBL2; NSLL; C-CBL; RNF55
Entrez GeneID: 867
Swissprot: P22681
WB Predicted band size: 120kDa
Host/Isotype: Mouse IgG1
Species Reactivity: Human,Mouse,Rat,Monkey,Rabbit
Immunogen : Purified recombinant fragment of human C-CBL expressed in E. Coli.
