This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Aliases： CDM; HCAD; LCAD; H-CAD; L-CAD; NAG22
Entrez GeneID ： 800
Swissprot： Q05682
WB Predicted band size： 93.2kDa
Host/Isotype ： Mouse IgG1
Species Reactivity ： Human
Immunogen： Purified recombinant fragment of human CALD1 (AA: 26-207) expressed in E. Coli.
