This gene encodes a G-protein coupled receptor 1 family member involved in the complement system of the innate immune response. Unlike classical G-protein coupled receptors, the encoded protein does not associate with intracellular G-proteins. It may instead modulate signal transduction through the beta-arrestin pathway, and may alternatively act as a decoy receptor. This gene may be involved in coronary artery disease and in the pathogenesis of sepsis. Alternative splicing results in multiple transcript variants.
Aliases : C5L2; GPF77; GPR77
Entrez GeneID: 27202
Swissprot: Q9P296
WB Predicted band size: 36kDa
Host/Isotype: Mouse IgG2b
Species Reactivity : Human
Immunogen : Purified recombinant fragment of human C5AR2 (AA: extra mix) expressed in E. Coli.
