This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Alternative splicing results in multiple transcript variants.
Aliases : AXIN; PPP1R49
Entrez GeneID : 8312
Swissprot : O15169
WB Predicted band size : 95.6kDa
Host/Isotype : Mouse IgG2b
Species Reactivity : Human
Immunogen : Purified recombinant fragment of human AXIN1 (AA: 546-752) expressed in E. Coli.
