This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. The protein forms a homodimer or heterodimer with c-Jun and stimulates CRE-dependent transcription. The protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. Additional transcript variants have been identified but their biological validity has not been determined.Tissue specificity: Abundant expression seen in the brain.
Aliases ：HB16; CREB2; TREB7; CRE-BP1; MGC111558; ATF2
Entrez GeneID ： 1386
Swissprot ： P15336
WB Predicted band size ： 55kDa
Host/Isotype ： Mouse IgG1
Species Reactivity ：Human,Mouse
Immunogen ：Purified recombinant fragment of human ATF2 expressed in E. Coli.
