The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus.
Aliases： ML8; KU70; TLAA; CTC75; CTCBF; G22P1
Entrez GeneID： 2547
Swissprot: P12956
WB Predicted band size： 69.8kDa
Host/Isotype： Mouse IgG1
Species Reactivity： Human
Immunogen ： Purified recombinant fragment of human XRCC6 (AA: 6-214) expressed in E. Coli.
