This gene encodes a phosphatidylinositol 3-phosphate-binding protein that functions as a master conductor for aggregate clearance by autophagy. This protein shuttles from the nuclear membrane to colocalize with aggregated proteins, where it complexes with other autophagic components to achieve macroautophagy-mediated clearance of these aggregated proteins. However, it is not necessary for starvation-induced macroautophagy.
Aliases： ALFY; BCHS; MCPH18; ZFYVE25
Entrez GeneID： 23001
Swissprot : Q8IZQ1
WB Predicted band size： 395kDa
Host/Isotype： Mouse IgG1
Species Reactivity ： Human
Immunogen： Purified recombinant fragment of human WDFY3 (AA: 3277-3526) expressed in E. Coli.
