The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.
Aliases: DR4; APO2; CD261; TRAILR1; TRAILR-1
Entrez GeneID: 8797
Swissprot: O00220
WB Predicted band size: 50kDa
Host/Isotype: Mouse IgG1
Species Reactivity: Human
Immunogen: Purified recombinant fragment of human TNFRSF10A (AA: extra 24-239) expressed in E. Coli.
