Synaptophysin (p38) is an integral membrane protein of small synaptic vesicles in brain and endocrine cells.Synaptophysin contains four transmembrane domains that form a hexameric channel or gap junction-like pore. Synaptophysin binds to the SNARE protein synaptobrevin/VAMP, which prevents the inclusion of synaptobrevin in the synaptic vesicle fusion complex and creates a pool of synaptobrevin for exocytosis when synapse activity increases. Synaptophysin is also responsible for targeting synaptobrevin 2/VAMP2 to synaptic vesicles, a critical component of the fusion complex.
Aliases： MRXSYP; SYP
Entrez GeneID： 6855
Swissprot： P08247
WB Predicted band size： 33.8kDa
Host/Isotype： Mouse IgG1
Species Reactivity： Human,Rat
Immunogen： Purified recombinant fragment of SYP expressed in E. Coli.
