The Stat3 transcription factor is an important signaling molecule for many cytokines and growth-factor receptors and is required for murine fetal development . Stat3 is constitutively activated in a number of human tumors and possesses oncogenic potential and anti-apoptotic activities. Stat3 is activated by phosphorylation at Tyr705, which induces dimerization, nuclear translocation and DNA binding. Transcriptional activation seems to be regulated by phosphorylation at Ser727 through the MAPK or mTOR pathways. Stat3 isoform expression appears to reflect biological function as the relative expression levels of Stat3a (86 kDa) and Stat3.
Aliases: APRF; HIES; FLJ20882; MGC16063; STAT3
Entrez GeneID: 6774
Swissprot: P40763
WB Predicted band size: 88kDa
Host/Isotype: Mouse IgG1
Species Reactivity: Human,Mouse,Monkey
Immunogen: Purified recombinant fragment of human STAT3 expressed in E. Coli.
