Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor-regulated SMAD (R-SMAD). SMAD5 is required for normal development of the cardiovascular system in vivo; lack of the SMAD5 gene results in apoptosis of cardiac myocytes. 3 Upregulation of SMAD5 has been reported to mediate apoptosis of gastric epithelial cells induced by Helicobacter pylori infection. Tissue specificity: Ubiquitous.
Aliases： Dwfc; JV5-1; MADH5; DKFZp781C1895; DKFZp781O1323; SMAD5
Entrez GeneID： 4090
Swissprot： Q99717
WB Predicted band size： 52kDa
Host/Isotype： Mouse IgG1
Species Reactivity： Human,Rat
Immunogen： Purified recombinant fragment of human SMAD5 expressed in E. Coli.
