The protein encoded by this gene is a member of the organic anion transporter (OAT) family, and it acts as a urate transporter to regulate urate levels in blood. This protein is an integral membrane protein primarily found in epithelial cells of the proximal tubule of the kidney. An elevated level of serum urate, hyperuricemia, is associated with increased incidences of gout, and mutations in this gene cause renal hypouricemia type 1. Alternative splicing results in multiple transcript variants.
Aliases： RST; OAT4L; URAT1
Entrez GeneID： 116085
Swissprot： Q96S37
WB Predicted band size： 59.6kDa
Host/Isotype： Mouse IgG1
Species Reactivity： Human, Mouse
Immunogen： Purified recombinant fragment of human SLC22A12 (AA: 30-145) expressed in E. Coli.
