This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Aliases： PAI; PAI1; PAI-1; PLANH1
Entrez GeneI：D 5054
Swissprot： P05121
WB Predicted band size： 45kDa
Host/Isotype： Mouse IgG1
Species Reactivity： Human,Mouse,Rat,Rabbit
Immunogen： Purified recombinant fragment of human SERPINE1 expressed in E. Coli.
