The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein.
Aliases： SDC; CD138; SYND1; syndecan
Entrez GeneID： 6382
Swissprot： P18827
WB Predicted band size： 32.5kDa
Host/Isotype： Mouse IgG1
Species Reactivity： Human,Mouse
Immunogen： Purified recombinant fragment of human SDC1 (AA: 28-171) expressed in E. Coli
