This gene encodes a type of GTPase-activating-protein (GAP) that down-regulates the activity of the ras-related RAP1 protein. RAP1 acts as a molecular switch by cycling between an inactive GDP-bound form and an active GTP-bound form. The product of this gene, RAP1GAP, promotes the hydrolysis of bound GTP and hence returns RAP1 to the inactive state whereas other proteins, guanine nucleotide exchange factors (GEFs), act as RAP1 activators by facilitating the conversion of RAP1 from the GDP- to the GTP-bound form. In general, ras subfamily proteins, such as RAP1, play key roles in receptor-linked signaling pathways that control cell growth and differentiation. RAP1 plays a role in diverse processes such as cell proliferation, adhesion, differentiation, and embryogenesis. Alternative splicing results in multiple transcript variants encoding distinct proteins.
Aliases: RAPGAP; RAP1GA1; RAP1GAP1; RAP1GAPII
Entrez GeneID: 5909
Swissprot: P47736
WB Predicted band size: 73.4kDa
Host/Isotype: Mouse IgG2b
Species Reactivity: Human
Immunogen: Purified recombinant fragment of human RAP1GAP (AA: 412-660) expressed in E. Coli.
