The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad21, a gene involved in the repair of DNA double-strand breaks, as well as in chromatid cohesion during mitosis. This protein is a nuclear phospho-protein, which becomes hyperphosphorylated in cell cycle M phase. The highly regulated association of this protein with mitotic chromatin specifically at the centromere region suggests its role in sister chromatid cohesion in mitotic cells.
Aliases: HR21; MCD1; NXP1; SCC1; CDLS4; hHR21; HRAD21
Entrez GeneID: 5885
Swissprot : O60216
WB Predicted band size: 71.7kDa
Host/Isotype: Mouse IgG1
Species Reactivity: Human,Rat,Monkey
Immunogen: Purified recombinant fragment of human RAD21 (AA: 287-403) expressed in E. Coli.
