Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis.
Aliases： COX2; COX-2; PHS-2; PGG/HS; PGHS-2; hCox-2; GRIPGHS
Entrez GeneID： 5743
Swissprot ： P35354
WB Predicted band size ： 69kDa
Host/Isotype： Mouse IgG1
Species Reactivity： Human
Immunogen： Purified recombinant fragment of human PTGS2 (AA: 18-207) expressed in E. Coli.
