The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support.
Aliases： PDJ; AR-JP; LPRS2; PARK2
Entrez GeneID： 5071
Swissprot ： O60260
WB Predicted band size： 51.6kDa
Host/Isotype ： Mouse IgG2a
Species Reactivity ： Human
Immunogen： Purified recombinant fragment of human PRKN (AA: 1-144) expressed in E. Coli.
