Protein-kinase-C-related kinases (PRKs) are part of the lipid-regulated protein kinases (PKC) which also include liver PAK & PKN. Human PRK1 and PRK2 share structurally similar catalytic domains, but less similar N-terminal regulatory regions suggesting different regulatory domain functions. PRK1 and PRK2, as well as a third member of this family, PRK3, show distinct patterns of expression in adult tissues. Additionally, the serine-threonine kinase PRK2 can be specifically cleaved by caspase-3 (and/or caspase-3-like subfamily members) during apoptosis.
Aliases： PKN2; PAK2; PRK2; Pak-2; PRKCL2; PRO2042; MGC71074; MGC150606
Entrez GeneID： 5586
Swissprot ： Q16513
WB Predicted band size： 140kDa
Host/Isotype： Mouse IgG1
Species Reactivity： Human,Mouse,Rat,Monkey
Immunogen： Purified recombinant fragment of human PRK2 expressed in E. Coli.
