This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA.
Aliases： RPB1; RPO2; POLR2; POLRA; RPBh1; RPOL2; RpIILS; hsRPB1; hRPB220
Entrez GeneID： 5430
Swissprot： P24928
WB Predicted band size： 217kDa
Host/Isotype： Mouse IgG2b
Species Reactivity： Human
Immunogen： Purified recombinant fragment of human POLR2A (AA: 128-258) expressed in E. Coli.
