PEG10: paternally expressed 10. This gene includes two overlapping reading frames of the same transcript encoding distinct isoforms. The shorter isoform has a CCHC-type zinc finger motif containing a sequence characteristic of gag proteins of most retroviruses and some retrotransposons, and it functions in part by interacting with members of the TGF-beta receptor family. The longer isoform has the active-site DSG consensus sequence of the protease domain of pol proteins. The longer isoform is the result of -1 translational frameshifting that is also seen in some retroviruses. Expression of these two isoforms only comes from the paternal allele due to imprinting. Increased gene _expression (as observed by an increase in mRNA levels) is associated with hepatocellular carcinomas.
Aliases： Edr; HB-1; Mar2; MEF3L; Mart2; RGAG3; KIAA1051
Entrez GeneID： 23089
Swissprot： Q86TG7
Host/Isotype： Mouse IgG1
Species Reactivity： Human
Immunogen： Purified recombinant fragment of PEG10 (aa1-120) expressed in E. Coli.
