Phosphoinositide-dependent kinase 1 (PDPK1, PDK1) is a serine/threonine protein kinase integral to the function of the PI 3-K/Akt signaling pathway. PDK1 and mTORC2 both phosphorylate and activate PKB/Akt, ensuring a cellular response to stimuli such as growth factors and insulin signaling. Akt is the main effector of PDK1.
Aliases： PDK1; PDPK2; PDPK2P; PRO0461
Entrez GeneID： 5170
Swissprot ： O15530
WB Predicted band size： 63.2kDa
Host/Isotype： Mouse IgG1
Species Reactivity： Human
Immunogen： Purified recombinant fragment of human PDPK1 (AA: 457-556 expressed in E. Coli.
