This gene encodes a member of the pyruvate dehydrogenase kinase family. The encoded protein phosphorylates pyruvate dehydrogenase, down-regulating the activity of the mitochondrial pyruvate dehydrogenase complex. Overexpression of this gene may play a role in both cancer and diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Aliases： PDHK2; PDKII
Entrez GeneID： 5164
Swissprot ： Q15119
WB Predicted band size ： 46.2kDa
Host/Isotype ： Mouse IgG2b
Species Reactivity： Human
Immunogen： Purified recombinant fragment of human PDK2 (AA: 178-404) expressed in E. Coli.
