This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit A, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit B. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Alternative splicing results in multiple transcript variants.
Aliases: PDGF1; PDGF-A
Entrez GeneID: 5154
Swissprot: P04085
WB Predicted band size: 24kDa
Host/Isotype: Mouse IgG2a
Species Reactivity: Human, Mouse
Immunogen: Purified recombinant fragment of human PDGFA (AA: 87-211) expressed in E. Coli.
