This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases.
Aliases: PDCD1; PD-1; CD279; SLEB2; hPD-1; hPD-l; hSLE1
Entrez GeneID: 5133
Swissprot: Q15116
WB Predicted band size : 31.6kDa
Host/Isotype: Mouse IgG2b
Species Reactivity : Human
Immunogen: Purified recombinant fragment of human PD1 (AA: 192-288) expressed in E. Coli.
