The protein encoded by this gene is a serine-threonine kinase and forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. Defects in this gene are the cause of non-syndromic mental retardation X-linked type 30 (MRX30), also called X-linked mental retardation type 47 (MRX47). Alternatively spliced transcript variants encoding different isoforms have been identified.
Aliases： ARA; bPAK; MRX30; MRX47; OPHN3; PAK-3; PAK3beta; beta-PAK
Entrez GeneID： 5063
Swissprot： O75914
WB Predicted band size： 62.3kDa
Host/Isotype ： Mouse IgG1
Species Reactivity： Human,Monkey
Immunogen： Purified recombinant fragment of human PAK3 (AA: 1-100) expressed in E. Coli.
