This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex.
Aliases： DSI,GIT,PDI,PHDB,PDIA1,PO4DB,PO4HB,PROHB,CLCRP1,ERBA2L,P4Hbeta
Entrez GeneID ： 5034
Swissprot： P07237
WB Predicted band size： 57.1kDa
Host/Isotype： Mouse IgG2a
Species Reactivity： Human
Immunogen： Purified recombinant fragment of human P4HB (AA: 309-508) expressed in Mammalian.
