This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.
Aliases: NRP1; NP1; NRP; BDCA4; CD304; VEGF165R
Entrez GeneID: 8829
Swissprot : O14786
WB Predicted band size : 103.1kDa
Host/Isotype: Mouse IgG1
Species Reactivity: Human
Immunogen: Synthesized peptide of human Neuropilin-1 (AA: 45-59).
