Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.Tissue specificity: Highly expressed in heart, skeletal muscle, spleen, thymus, prostate, testis, ovary, colon and leukocytes.
Aliases ： NEDD-8
Entrez GeneID： 4738
Swissprot ： Q15843
WB Predicted band size ： 9kDa
Host/Isotype： Mouse IgG1
Species Reactivity： Human
Immunogen ： Purified recombinant fragment of human NEDD8 expressed in E. Coli.
