The TUG protein contains a UBX domain, for GLUT4. In truncated form, TUG acts in a dominant-negative manner to inhibit insulin-stimulated GLUT4 redistribution in Chinese hamster ovary cells and 3T3-L1 adipocytes. Full-length TUG forms a complex specifically with GLUT4. In 3T3-L1 adipocytes, this complex is present in unstimulated cells and is largely disassembled by insulin. Endogenous TUG is localized with the insulin-mobilizable pool of GLUT4 in unstimulated 3T3-L1 adipocytes, and is not mobilized to the plasma membrane by insulin.
Aliases： ASPCR1, ASPL, ASPS, RCC17, TUG, UBXD9, UBXN9
Entrez GeneID： 79058
Swissprot ： Q9BZE9
Host/Isotype： Mouse IgG1
Species Reactivity： Mouse
Immunogen： Purified recombinant fragment of TUG expressed in E. Coli.
