This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. Alternative splicing results in multiple transcript variants.
Aliases: PERB11.2
Entrez GeneID: 4277
Swissprot: Q29980
WB Predicted band size: 42.6kDa
Host/Isotype : Mouse IgG1
Species Reactivity: Human
Immunogen : Purified recombinant fragment of human MICB (AA: extra 23-309) expressed in HEK293-6e cells supernatant.
