This gene encodes a protein containing multiple ankyrin repeats and RING finger domains that functions as an E3 ubiquitin ligase. The encoded protein positively regulates Notch signaling by ubiquitinating the Notch receptors, thereby facilitating their endocytosis. This protein may also promote the ubiquitination and degradation of death-associated protein kinase 1 (DAPK1).
Aliases : MIB; DIP1; ZZZ6; DIP-1; LVNC7; ZZANK2
Entrez GeneID: 57534
Swissprot: Q86YT6
WB Predicted band size: 110kDa
Host/Isotype : Mouse IgG1
Species Reactivity: Human,Monkey
Immunogen : Purified recombinant fragment of human MIB1 (AA: 6-221) expressed in E. Coli.
