This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.
Aliases： DMX; hdm2; ACTFS
Entrez GeneID： 4193
Swissprot ： Q00987
WB Predicted band size ： 55.2kDa
Host/Isotype： Mouse IgG1
Species Reactivity ： Human
Immunogen ： Synthesized peptide of human MDM2 (AA: cSRPSTSSRRRAISE).
