This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8.
Aliases： PARK8; RIPK7; ROCO2; AURA17; DARDARIN
Entrez GeneID： 120892
Swissprot： Q5S007
WB Predicted band size： 286kDa
Host/Isotype ： Mouse IgG1
Species Reactivity ： Human
Immunogen ： Purified recombinant fragment of human LRRK2 (AA: 300-530) expressed in E. Coli.
